Therefore, when atorlip-ez ezetimibe is added to statin therapy, monitor hepatic transaminase levels before and during treatment according to the recommendations for the individual statin used.
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Colstipol: Plasma concntations atovastatin and its activ mtabolits w low (by appox. 25%) whn colstipol was co-administd with atovastatin. Howv, lipid cts w gat whn atovastatin and colstipol w co-administd than whn ith mdicinal poduct was givn alon.
In animal modls, atovastatin lows plasma cholstol and lipopotin lvls by inhibiting HMG-CoA ductas and cholstol synthsis in th liv and by incasing th numb hpatic LDL cptos on th cll suac tnhanc uptak and catabolism LDL; atovastatin alsducs LDL poduction and th numb LDL paticls.
Poton Pump Inhibitos : Avoid concomitant us ATOLIP CV with ompazol sompazol. In clinical studis, ompazol was shown tduc th antiplatlt activity clopidogl whn givn concomitantly 12 hous apat. A high dos gimn clopidogl concomitantly administd with ompazol incass antiplatlt spons; an appopiat dos gimn has not bn stablishd. A simila duction in antiplatlt activity was obsvd with sompazol whn givn concomitantly with clopidogl. Consid using anoth acid-ducing agnt with minimal nCYP2C19 inhibitoy ct on th omation clopidogl activ mtabolit. Dxlansopazol, lansopazol and pantopazol had lss ct on th antiplatlt activity clopidogl than did ompazol sompazol.
A cass habdomyolysis with acut nal ailu sconday tmyoglobinuia hav bn potd with atovastatin and with oth dugs in this class. A histoy nal impaimnt may b a isk actth dvlopmnt habdomyolysis. Such patints mit clos monitoing skltal muscl cts.
Duc th isk non-atal MI duc th isk atal and non-atal stok duc th isk vasculaization pocdus duc th isk hospitalization CH duc th isk angina.
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